Water → HCID 86736330, Verbindung

HRID 1390788Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1390788
[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:14]([CH2:15][C@@H:16]([OH:28])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2].F[B-](F)(F)F.[CH2:34]([O+](CC)CC)[CH3:35].O>C(Cl)Cl>[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:14]([CH2:15][C@@H:16]([O:28][CH2:34][CH3:35])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 962WaterHCID 2723982Triethyloxonium tetrafluoroborateHCID 70604761HCID 70604761, Verbindung

Produkt 1

HCID 86736330HCID 86736330, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5-Androstene-3β,17β,19-triol 17,19-diacetate is dissolved in methylenechloride and triethyloxonium fluoroborate added thereto. After stirring for a period of about two hours at room temperature, water is added to the reaction mixture. The methylenechloride layer is dried over magnesium sulfate and concentrated to dryness. The residue is crystallized from an acetone-hexane mixture to yield the desired 3β-ethoxy-5-androstene-17β,19-diol diacetate.

Aufarbeitung

  1. dry with materialThe methylenechloride layer is dried over magnesium sulfate
  2. concentrationconcentrated to dryness
  3. customThe residue is crystallized from an acetone-hexane mixture

Quellen und Nachweise

ORD-Eintrag
ord-65f4e78653ba4f05b345502968f47227
Quelldatensatz
uspto-grants-1979_02
Patentnummer
US04139617

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