Acetic Acid → [4-(2-Bromoethyl)phenyl]acetic acid

HRID 1391183Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1391183
[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7](CC#N)=[CH:6][CH:5]=1.[C:13]([OH:16])(=[O:15])[CH3:14]>Br>[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:14][C:13]([OH:16])=[O:15])=[CH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 20386067HCID 20386067, Verbindung

Produkt 1

HCID 20386065[4-(2-Bromoethyl)phenyl]acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 260Hydrogen BromideLösungsmittel

Versuchsvorschrift

A solution of [4-(2-bromoethyl)phenyl]acetonitrile (56.0 g., 0.25 mole) in 48% hydrobromic acid (200 ml.) and acetic acid (600 ml.) is boiled under reflux for 4 hours. The solution is reduced to one-third volume by distillation at reduced pressure. The residue is diluted with 400 ml. of water to force out the oily product which is taken up in ether, washed with water, and dried over sodium sulfate. Evaporation of the solvent leaves the title compound as a residual oil.

Aufarbeitung

  1. temperatureunder reflux for 4 hours
  2. distillationThe solution is reduced to one-third volume by distillation at reduced pressure
  3. additionThe residue is diluted with 400 ml
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-0ba67f43bb54494f822f54116dafa631
Quelldatensatz
uspto-grants-1979_02
Patentnummer
US04140861

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