Ethylamine → N1-Ethyl-4-nitro-1,2-phenylenediamine
Reaktionsgleichung
F[C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH2:4].[CH2:12]([NH2:14])[CH3:13]>>[CH2:12]([NH:14][C:2]1[C:3]([NH2:4])=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[CH:7][CH:8]=1)[CH3:13]Komponenten
3
Versuchsvorschrift
2-fluoro-5-nitroaniline (5 g, 32 mmol) and a solution of ethyl amine (32 ml, 2M in THF) were coupled according to the procedure of intermediate example one part A to give the title compound as a dark red solid 4.16 g, 72%). 1H NMR (300 MHz, d6-DMSO) δ7.51 (dd, J=8.7 and 2.7 Hz, 1H), 7.38 (d, J=2.7 Hz, 1H), 6.44 (d, J=8.7 Hz, 1H), 5.86 (t, J=4.6 Hz, 1H), 5.15 (s, 2H), 3.20 (m, 2H), 1.21 (t, J=7.2 Hz, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-21ef47374b4747ddaf6c50780fb33cfc
- Quelldatensatz
- uspto-grants-2008_03
- Patentnummer
- US07338959B2
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