Cyanogen Bromide → 1-methyl-5-nitro-1H-benzimidazol-2-amine

HRID 1391546Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1391546
[CH3:1][NH:2][C:3]1[C:4]([NH2:12])=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[CH:7][CH:8]=1.[N:13]#[C:14]Br>CO>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=2[N:12]=[C:14]1[NH2:13]

Komponenten

4

Edukt 2

HCID 10476Cyanogen BromideHCID 34200251-N-methyl-4-nitrobenzene-1,2-diamine

Produkt 1

HCID 450786361-methyl-5-nitro-1H-benzimidazol-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of N1-methyl-4-nitro-benzene-1,2-diamine (200 mg, 1.20 mmol) in methanol (12 ml) was added cyanogen bromide (190.1 mg, 1.79 mmol). After stirring at room temperature for 16 h, the methanol was removed in vacuo and the resulting solid was stirred with diethyl ether (40 ml) for 5 minutes. The resulting hydrobromide salt of the title compound was filtered and air-dried.

Aufarbeitung

  1. customthe methanol was removed in vacuo
  2. stirringthe resulting solid was stirred with diethyl ether (40 ml) for 5 minutes
  3. filtrationThe resulting hydrobromide salt of the title compound was filtered
  4. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-a44532fd00534422a86455a70c8c0659
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07338959B2

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