3-(Pyrimidin-2-yl)prop-2-yn-1-ol → 2-Pyrimidinepropanol

HRID 1392133Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1392133
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][OH:10]>C(OCC)(=O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10]

Komponenten

4

Edukt 1

HCID 219193933-(Pyrimidin-2-yl)prop-2-yn-1-ol

Produkt 1

HCID 109755572-Pyrimidinepropanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-(2-pyrimidyl) prop-2-yn-1-ol (4.45 g; 0.033 M) was dissolved in ethyl acetate (140 mL), 10% Pd/C (890 mg) was added and the mixture stirred under an atmosphere of hydrogen for 6 hours. The reaction mixture was filtered through Celite and the filtrate evaporated to give 3-(2-pyrimidyl) propan-1-ol as a yellow oil, 4.15 g (91%). NMR (CDCl3) 2.1 (2H, m), 3.2 (2H, t), 3.8 (2H, t), 7.2 (1H, t), 8.7 (2H, d) MS found MH+139.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe filtrate evaporated

Quellen und Nachweise

ORD-Eintrag
ord-2e5bcee9f458446588b2496890e02045
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07342020B2

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