Water → 1-[2-(4-Allyloxy-benzyloxy)-ethyl]-1H-[1,2,3]triazole

HRID 1392223

Reaktionsgleichung

Reaktionsgleichung von HRID 1392223
[H-].[Na+].[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13]Cl)=[CH:9][CH:8]=1)[CH:4]=[CH2:5].[N:15]1([CH2:20][CH2:21][OH:22])[CH:19]=[CH:18][N:17]=[N:16]1.O>CN(C=O)C>[CH2:3]([O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][O:22][CH2:21][CH2:20][N:15]2[CH:19]=[CH:18][N:17]=[N:16]2)=[CH:9][CH:8]=1)[CH:4]=[CH2:5]

Komponenten

6

Edukt 4

HCID 962WaterHCID 24758Sodium hydrideHCID 99892372-(1H-1,2,3-triazol-1-yl)ethan-1-olHCID 123479361-Allyloxy-4-chloromethyl-benzene

Produkt 1

HCID 236145301-[2-(4-Allyloxy-benzyloxy)-ethyl]-1H-[1,2,3]triazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

197 mg (8.21 mmol) 95% sodium hydride were given at −50° C. to a solution of 1.00 g (5.47 mmol) 1-allyloxy-4-chloromethyl-benzene and 619 mg (5.47 mmol) 2-(1H-[1,2,3]-triazol-1-yl)-ethanol in 9.0 ml DMF. The mixture was allowed to warm slowly to r.t., stirred overnight and 10 ml water was added. The formed oil was collected with 10 ml dichloromethane, the aqueous phase extracted with 10 ml dichloromethane and the combined organic phases dried over Na2SO4.

Aufarbeitung

  1. customThe formed oil was collected with 10 ml dichloromethane
  2. extractionthe aqueous phase extracted with 10 ml dichloromethane
  3. dry with materialthe combined organic phases dried over Na2SO4

Quellen und Nachweise

ORD-Eintrag
ord-6ac6895bd391446c9673193b163839f5
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07342030B2

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