Hydrogen chloride-ethyl acetate → HCID 69312995, Verbindung

HRID 1392411Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1392411
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]1([C:15]([NH:17][CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH:19]2[OH:31])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7].[ClH:32].C(OCC)(=O)C>C(OCC)C>[ClH:32].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]1([C:15]([NH:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH:19]2[OH:31])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7]

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 693103074-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-tert-butoxycarbonyl-3-piperidinol

Produkt 1

HCID 69312995HCID 69312995, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

The solution of 4-{1-[N-(furan-2-ylcarbonyl)amino]cyclohexane carbonyl}amino-1-tert-butoxycarbonyl-3-piperidinol (30 g) obtained in Step 3 in 100 ml of 3N-hydrochloride/ethyl acetate was stirred for about 2 hours at room temperature. 100 ml of diethyl ether was added to the reaction mixture, and then the resulting white solid was filtered and dried to give 3.6 g of the titled compound.

Aufarbeitung

  1. filtrationthe resulting white solid was filtered
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-e7dc10ff0d1949d3b6719441892f4b7a
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07342027B2

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