Hydrochloric Acid → Oxane-4-carboxylic acid

HRID 1392745Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1392745
[O:1]1[CH2:6][CH2:5][C:4](C(OC)=O)([C:7]([O:9]C)=[O:8])[CH2:3][CH2:2]1.Cl>O>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 11063483Dimethyl Tetrahydropyran-4,4-dicarboxylate

Produkt 1

HCID 219302Oxane-4-carboxylic acidAusbeute 101,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Dimethyl tetrahydro-4H-pyrane-4,4-dicarboxylate (4.04 g) was added to 20% hydrochloric acid (20 ml), and the mixture was heated under reflux for 19 hours. Water was added to the reaction mixture to conduct extraction with diethyl ether. After the resultant organic layer was washed with saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. After the resultant residue was solidified with hexane, the resultant solides were collected by filtration and washed to obtain the title compound (2.63 g).

Aufarbeitung

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 19 hours
  3. extractionextraction with diethyl ether
  4. washAfter the resultant organic layer was washed with saturated aqueous solution of sodium chloride
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled off under reduced pressure
  7. filtrationthe resultant solides were collected by filtration
  8. washwashed

Quellen und Nachweise

ORD-Eintrag
ord-f62329502af442e9a42160b2ecf5e261
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07342014B2

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