Nitric Acid → 2-(3-Methoxy-propyl)-4-nitro-phenoxy-acetic acid ethyl ester

HRID 1393095Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1393095
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][O:16][CH3:17])[CH3:2].[N+:19]([O-])([OH:21])=[O:20]>C(OC(C(F)(F)F)=O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N+:19]([O-:21])=[O:20])=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][O:16][CH3:17])[CH3:2]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 67072081HCID 67072081, Verbindung

Produkt 1

HCID 670724332-(3-Methoxy-propyl)-4-nitro-phenoxy-acetic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9845Trifluoroacetic anhydrideLösungsmittel2×

Versuchsvorschrift

4.00 g (15.9 mmol) of the above prepared [2-(3-methoxy-propyl)-phenoxy]-acetic acid ethyl ester was dissolved in 5.0 ml of TFAA and added slowly and carefully via dropping funnel to a mixture of 5 ml of TFAA and 4 ml of conc. HNO3 (65%) kept at −10° C.; the reaction was then allowed to proceed for additional 30 min. Careful quenching with ice, twofold extraction with EtOAc, washing with NaHCO3 and brine, drying over magnesium sulfate, and evaporation of the solvents left a crude product which was purified by flash chromatography (SiO2, hexane/EtOAc=75/25) to deliver finally 3.00 g of the title compound as light brown oil, contaminated according to NMR with roughly 35% of the ortho-isomer which was separated after the next step, MS: 298.3 (MH+)+.

Aufarbeitung

  1. additionadded slowly
  2. customkept at −10° C.
  3. customCareful quenching with ice, twofold extraction with EtOAc
  4. washwashing with NaHCO3 and brine
  5. dry with materialdrying over magnesium sulfate, and evaporation of the solvents
  6. waitleft a crude product which
  7. customwas purified by flash chromatography (SiO2, hexane/EtOAc=75/25)
  8. customwas separated after the next step, MS

Quellen und Nachweise

ORD-Eintrag
ord-6ac52fe3a37a478b9023a7e60f289b3b
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07345067B2

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