HCID 23092000, Verbindung → 1-acetylindoline-5-carboxylic acid

HRID 1393674Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1393674
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([O:15]CC3C=CC=CC=3)=[O:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 23092000HCID 23092000, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 52955471-acetylindoline-5-carboxylic acidAusbeute 48 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

The benzyl 1-acetyl-1H-indole-5-carboxylate (550 mg) obtained above was suspended in ethanol (9 ml). 10% Palladium on carbon was added thereto, and the mixture was stirred for 16 hours at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure. Precipitated crystals were collected by filtration, washed with ether and dried under reduced pressure to give the title compound (180 mg, Y.:48%).

Aufarbeitung

  1. customInsoluble matter was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPrecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with ether
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5a12ce0a24374569b20aba7653d7cafe
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07345180B2

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