Chloroform → 7,9-Dibromo-beta-carboline hydrochloride

HRID 1393976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1393976
[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[NH:12]2)=[CH:4][CH:3]=1.[Br:15]Br.C(Cl)(Cl)[Cl:18]>C1COCC1>[ClH:18].[Br:1][C:2]1[CH:14]=[C:13]2[C:5]([C:6]3[CH:7]=[CH:8][N:9]=[CH:10][C:11]=3[N:12]2[Br:15])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6212ChloroformHCID 24408BromineHCID 145928Eudistomin O

Produkt 1

HCID 221852417,9-Dibromo-beta-carboline hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of the product from example 1 (140 mg, 0.58 mmol) in THF (2 ml) was treated with bromine (0.50 ml). After 10 min at RT, the reaction was diluted with chloroform and the product was filtered. The filtered product was taken up in methanol and treated with 1M HCl in ether and concentrated. The residue was triturated with ether to provide 160 mg of 7,9-dibromo-β-carboline hydrochloride.

Aufarbeitung

  1. filtrationthe product was filtered
  2. additiontreated with 1M HCl in ether
  3. concentrationconcentrated
  4. customThe residue was triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-211396885c9740f4af7d0f49fd64b55d
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07348336B2

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