Sodium Methoxide → 2,4-Dimethoxy-5-nitropyridine

HRID 1394224

Reaktionsgleichung

Reaktionsgleichung von HRID 1394224
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1.[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 10942334Sodium MethoxideHCID 441196732-Chloro-4-methoxy-5-nitropyridine

Produkt 1

HCID 513584872,4-Dimethoxy-5-nitropyridineAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of the product of Step 2 (950 mg, 5 mmol), sodium methoxide (695 mg, 12.5 mmol) in methanol (10 ml) was heated at reflux for 2 hours. After cooling the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried and evaporated in vacuo to give the title compound (900 mg, 98%). MS (ES+) m/e 185 [M+H]+.

Aufarbeitung

  1. temperatureat reflux for 2 hours
  2. temperatureAfter cooling the solvent
  3. customwas removed in vacuo
  4. customthe residue partitioned between ethyl acetate and water
  5. washThe organic phase was washed with water and brine
  6. customdried
  7. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e370cd43028748c99eff0354a3683c90
Quelldatensatz
uspto-grants-2008_03
Patentnummer
US07348339B2

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