Ethylene Oxide → 2-[Benzyl(2-hydroxyethyl)amino]benzamide

HRID 1395804Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395804
[CH2:1]([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]1[O:20][CH2:19]1>C(O)(=O)C>[CH2:1]([N:8]([CH2:18][CH2:19][OH:20])[C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 6354Ethylene OxideHCID 11345158HCID 11345158, Verbindung

Produkt 1

HCID 203383632-[Benzyl(2-hydroxyethyl)amino]benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

o-Benzylaminobenzamide (62 g) was added to a cold solution of 85 ml ethylene oxide in 500 ml acetic acid, the mixture stirred 22 hours at room temperature and concentrated on the rotovap to remove 250 ml acetic acid. The remainder was made alkaline with 10% NaOH and the solid filtered washed with water and recrystallized from 300 ml ethyl acetate to give 48.5 g. product, m. 133-7.

Aufarbeitung

  1. concentrationconcentrated on the rotovap
  2. customto remove 250 ml acetic acid
  3. filtrationthe solid filtered
  4. washwashed with water
  5. customrecrystallized from 300 ml ethyl acetate
  6. customto give 48.5 g

Quellen und Nachweise

ORD-Eintrag
ord-eea9a560cead4d6395ea84d6a9a4e48c
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04205173

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