Hydrochloric Acid → HCID 178501377, Verbindung

HRID 1395812Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395812
[CH3:1][O:2][C:3](=[O:42])[C@H:4]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH:30]([CH3:32])[CH3:31])[NH:8][C:9](=[O:29])[C@H:10]([CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:28])[NH2:27])[N:11](C(OC(C)(C)C)=O)[N+:12]([O-:14])=[O:13].[ClH:43]>C(O)(=O)C.O1CCOCC1>[ClH:43].[CH3:1][O:2][C:3](=[O:42])[C@H:4]([CH2:34][C:35]1[CH:40]=[CH:39][C:38]([OH:41])=[CH:37][CH:36]=1)[NH:5][C:6](=[O:33])[C@H:7]([CH:30]([CH3:32])[CH3:31])[NH:8][C:9](=[O:29])[C@H:10]([CH2:22][CH2:23][CH2:24][NH:25][C:26](=[NH:27])[NH2:28])[NH:11][N+:12]([O-:14])=[O:13]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 178501376HCID 178501376, Verbindung

Produkt 1

HCID 178501377HCID 178501377, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

30.9 g of t-butoxycarbonylnitroarginylvalyltyrosine methyl ester is dissolved in 177 ml of acetic acid. To this solution is added 88.5 ml of 6 N hydrochloric acid in dioxane. The reaction is allowed to stand for five minutes and the solvent is removed under vacuum. The residue is triturated with ethyl ether. The resultant precipitate is filtered, washed with ethyl ether and dried in a vacuum oven at 55° C. to afford nitroarginylvalyltyrosine methyl ester hydrochloride.

Aufarbeitung

  1. customthe solvent is removed under vacuum
  2. customThe residue is triturated with ethyl ether
  3. filtrationThe resultant precipitate is filtered
  4. washwashed with ethyl ether
  5. customdried in a vacuum oven at 55° C.

Quellen und Nachweise

ORD-Eintrag
ord-52b7b15ba7a8458c93963d1ed57909ba
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04204991

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