Hydrochloric Acid → HCID 178465149, Verbindung

HRID 1395822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1395822
C[O:2][C:3](=[O:77])[C:4](=[CH2:76])[NH:5][C:6](=[O:75])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:74])[C@H:13]([CH2:68][C:69]1[N:73]=[CH:72][NH:71][CH:70]=1)[NH:14][C:15](=[O:67])[C@H:16]([C@H:63]([CH2:65][CH3:66])[CH3:64])[NH:17][C:18](=[O:62])[C@H:19]([CH2:54][C:55]1[CH:60]=[CH:59][C:58]([OH:61])=[CH:57][CH:56]=1)[NH:20][C:21](=[O:53])[C@H:22]([CH:50]([CH3:52])[CH3:51])[NH:23][C:24](=[O:49])[C@H:25]([CH2:42][CH2:43][CH2:44][NH:45][C:46](=[NH:48])[NH2:47])[N:26]([C:30](=[O:41])[CH2:31][N:32]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH3:33])[N+:27]([O-:29])=[O:28].[OH-].[Li+].Cl>O1CCOCC1>[C:37]([O:36][C:34]([N:32]([CH2:31][C:30]([N:26]([N+:27]([O-:29])=[O:28])[C@H:25]([C:24]([NH:23][C@H:22]([C:21]([NH:20][C@H:19]([C:18]([NH:17][C@H:16]([C:15]([NH:14][C@H:13]([C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:6]([NH:5][C:4]([C:3]([OH:77])=[O:2])=[CH2:76])=[O:75])=[O:74])[CH2:68][C:69]1[N:73]=[CH:72][NH:71][CH:70]=1)=[O:67])[C@H:63]([CH2:65][CH3:66])[CH3:64])=[O:62])[CH2:54][C:55]1[CH:60]=[CH:59][C:58]([OH:61])=[CH:57][CH:56]=1)=[O:53])[CH:50]([CH3:51])[CH3:52])=[O:49])[CH2:42][CH2:43][CH2:44][NH:45][C:46](=[NH:47])[NH2:48])=[O:41])[CH3:33])=[O:35])([CH3:40])([CH3:38])[CH3:39]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178465150HCID 178465150, Verbindung

Produkt 1

HCID 178465149HCID 178465149, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2.09 g of t-butoxycarbonylsarcosylnitroarginylvalyltyrosylisoleucylhistidylprolyldehydroalanine methyl ester is dissolved in 30 ml of dioxane. To this solution is added 60 ml of 1 N lithium hydroxide. The reaction mixture is stirred for three hours, then neutralized with 1 N hydrochloric acid to pH 7. The solvent is removed by vacuum and the residue is dissolved in N,N-dimethylformamide. Ths solution is filtered and the solvent removed by vacuum. The residue is dissolved in dioxane and added to 300 ml of cold rapidly stirring ethyl ether. The precipate is filtered and dried in vacuo to afford t-butoxycarbonylsarcosylnitroarginylvalyltyrosylisoleucylhistidylprolyldehydroalanine.

Aufarbeitung

  1. customThe solvent is removed by vacuum
  2. dissolutionthe residue is dissolved in N,N-dimethylformamide
  3. filtrationThs solution is filtered
  4. customthe solvent removed by vacuum
  5. dissolutionThe residue is dissolved in dioxane
  6. additionadded to 300 ml of cold rapidly stirring ethyl ether
  7. filtrationThe precipate is filtered
  8. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e8940fc6362646668d5fb0de49810923
Quelldatensatz
uspto-grants-1980_05
Patentnummer
US04204991

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