3-(4-Fluorophenoxy)propionic acid → Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonate

HRID 1396689

Reaktionsgleichung

Reaktionsgleichung von HRID 1396689
[NH2:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4].[F:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH2:17][CH2:18][C:19](O)=[O:20])=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:23]=[CH:22][C:15]([O:16][CH2:17][CH2:18][C:19]([NH:1][CH:2]([C:7]([O:9][CH3:10])=[O:8])[C:3]([O:5][CH3:6])=[O:4])=[O:20])=[CH:14][CH:13]=1

Komponenten

3

Edukt 2

HCID 740993-(4-Fluorophenoxy)propionic acidHCID 437601Dimethyl aminomalonate hydrochloride

Produkt 1

HCID 50941576Dimethyl 2-(3-(4-fluorophenoxy)propanamido)malonateAusbeute 80 %

Versuchsvorschrift

This compound was synthesized from dimethyl aminomalonate according to the procedure for the preparation of example 2 using 3-(4-fluorophenoxy)propionic acid. The crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1) to yield the title compound as a white solid (80%).

Aufarbeitung

  1. customThe crude residue was purified by flash chromatography on silica (CH2Cl2/MeOH 50:1)

Quellen und Nachweise

ORD-Eintrag
ord-65a150ca252845d0888cf704465dbc65
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901132B2

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