N,N,4-Trimethyl-5-nitropyridin-2-amine → N2,N2,4-trimethylpyridine-2,5-diamine

HRID 1398859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1398859
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([N+:10]([O-])=O)=[CH:5][N:4]=1>C(O)C.[Pd]>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([NH2:10])=[CH:5][N:4]=1

Komponenten

4

Edukt 1

HCID 21857174N,N,4-Trimethyl-5-nitropyridin-2-amine

Produkt 1

HCID 22136281N2,N2,4-trimethylpyridine-2,5-diamineAusbeute 119,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of N,N,4-trimethyl-5-nitropyridin-2-amine (15.7 g, 86.6 mmol) in ethanol (200 ml) was added 10% palladium on carbon (50% wet, 1.57 g), and the mixture was purged with hydrogen and stirred under balloon pressure hydrogen at room temperature for 2 days. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a brown solid (15.7 g), which was used next reaction without purification.

Aufarbeitung

  1. customthe mixture was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5a655849ed2d497aa32f9b8103bee117
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901141B2

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