N,N,6-trimethyl-5-nitropyridin-2-amine → N2,N2,6-trimethylpyridine-2,5-diamine

HRID 1398861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1398861
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[C:5]([CH3:12])[N:4]=1>O1CCCC1.[Pd]>[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([CH3:12])[N:4]=1

Komponenten

4

Edukt 1

HCID 59613085N,N,6-trimethyl-5-nitropyridin-2-amine

Produkt 1

HCID 20748032N2,N2,6-trimethylpyridine-2,5-diamineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of N,N,6-trimethyl-5-nitropyridin-2-amine (2.73 g, 15.1 mmol) in tetrahydrofuran (50 mL) was added 10% palladium on carbon (50% wet, 273 mg), and the mixture was purged with hydrogen and stirred under balloon pressure hydrogen at room temperature for 14 hr. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a brown solid (2.30 g, 15.1 mmol).

Aufarbeitung

  1. customthe mixture was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0c47b4cebc9044bbaced7217322c58ff
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08901141B2

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