Piperidine-1-carboxamidine → HCID 178447459, Verbindung

Reaktionsgleichung

[N:1]1([C:7](=[NH:9])[NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:10]([C:25](OCC)=[O:26])([C:20](OCC)=[O:21])[CH:11]([C:15]([O:17]CC)=[O:16])[CH2:12][CH2:13][CH3:14].C[O-].[Na+]>CO>[OH:21][C:20]1[C:10]([CH:11]([CH2:12][CH2:13][CH3:14])[C:15]([OH:17])=[O:16])=[C:25]([OH:26])[N:8]=[C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[N:9]=1

Komponenten

Versuchsvorschrift

To a solution of piperidine-1-carboximidamide (dimer complexated with H2SO4) (1.32 g; 10.4 mmol) and triethyl pentane-1,1,2-tricarboxylate (3 g; 10.4 mmol) in methanol (15 mL) was slowly added a solution of sodium methoxide in methanol (25% w:w) (4.76 mL; 20.81 mmol) and the reaction was heated to reflux for 18 h. The volatiles were removed under reduced pressure and the crude residue was used as such in the next reaction.