Hydrochloric Acid → HCID 68151396, Verbindung

HRID 1400293Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1400293
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH:15]C(=O)OC(C)(C)C.[ClH:23]>C(OCC)C.O1CCOCC1>[Cl-:23].[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[O:12][CH2:13][CH2:14][NH3+:15]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 86709754HCID 86709754, Verbindung

Produkt 1

HCID 68151396HCID 68151396, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a cooled (0° C.) single necked flask containing a solution of tert-butyl {2-[(1-fluoronaphthalen-2-yl)oxy]ethyl}carbamate in 5 mL of ethyl ether, 5 mL of 4 M HCl solution in dioxane were added. The resulting mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated under reduce pressure to afford 2-[(1-fluoronaphthalen-2-yl)oxy]ethanaminium chloride as a white solid (95% yield) which was pure by TLC and NMR analysis.

Aufarbeitung

  1. additionwere added
  2. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-eca7b5b7cf784964883089e8fdc6d479
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08906946B2

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