3-Nitro[1,1'-biphenyl]-2-amine → 102877-92-9

HRID 1401118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1401118
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>[Fe].CC(O)=O>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 131499333-Nitro[1,1'-biphenyl]-2-amine

Produkt 1

HCID 18968019102877-92-9

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2-Amino-3-nitrobiphenyl d (0.613 g, 2.86 mmol) was purged under nitrogen for 30 minutes then HOAc (5 mL) was added followed by iron powder (0.4895 g, 8.76 mmol). The sample was heated at 60° C. for 30 minutes then HOAc (5 mL) was added. The sample was stirred at 60° C. for 1 hour then poured into ice. The sample was extracted with EtOAc (3×100 mL). The EtOAc extracts were washed with saturated NaHCO3 (3×100 mL. The EtOAc layer was dried over MgSO4, filtered, and concentrated to give 2,3-diaminobiphenyl e (0.439 g, 2.38 mmol, 83%).

Aufarbeitung

  1. customwas purged under nitrogen for 30 minutes
  2. additionHOAc (5 mL) was added
  3. additionthen poured into ice
  4. extractionThe sample was extracted with EtOAc (3×100 mL)
  5. washThe EtOAc extracts were washed with saturated NaHCO3 (3×100 mL
  6. dry with materialThe EtOAc layer was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8eb068e5d8fc4e4081fa55a501164e4d
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08907092B2

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