2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one → 4-{1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]azepan-4-ylamino}butan-1-ol

HRID 1401850

Reaktionsgleichung

Reaktionsgleichung von HRID 1401850
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9][C:8]([CH3:18])([CH3:17])[C:7]=2[CH:6]=1)=O.[OH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH:25]1[CH2:31][CH2:30][CH2:29][N:28]([C:32](=[S:34])[NH2:33])[CH2:27][CH2:26]1>>[CH3:15][C:11]1([CH3:16])[CH2:10][CH2:9][C:8]([CH3:17])([CH3:18])[C:7]2[CH:6]=[C:5]([C:3]3[N:33]=[C:32]([N:28]4[CH2:29][CH2:30][CH2:31][CH:25]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][OH:19])[CH2:26][CH2:27]4)[S:34][CH:2]=3)[CH:14]=[CH:13][C:12]1=2

Komponenten

3

Edukt 2

HCID 28013372-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-oneHCID 866718284-(4-Hydroxybutylamino)azepane-1-carbothioamide

Produkt 1

HCID 533114564-{1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]azepan-4-ylamino}butan-1-ol

Versuchsvorschrift

The preparation is carried out as already described starting from 508 mg (1.15 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and the product from step c. The purification was carried out by means of preparative HPLC. The product is in the form of the hydrochloride.

Aufarbeitung

  1. customThe purification

Quellen und Nachweise

ORD-Eintrag
ord-288bc318ac094b09baa7444ed4b7929f
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08907098B2

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