2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one → 4-{1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]azepan-4-ylamino}butan-1-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one	HCID 2801337	—
Edukt	4-(4-Hydroxybutylamino)azepane-1-carbothioamide	HCID 86671828	—
Produkt	4-{1-[4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)thiazol-2-yl]azepan-4-ylamino}butan-1-ol	HCID 53311456	—

Reaktionsschritte

The preparation is carried out as already described starting from 508 mg (1.15 mmol) of 2-bromo-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone and the product from step c. The purification was carried out by means of preparative HPLC. The product is in the form of the hydrochloride.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08907098B2
Quelldatensatz	uspto-grants-2014_12
ORD ID	ord-288bc318ac094b09baa7444ed4b7929f
Quellennotiz	uspto-grants-2014_12