Water → HCID 67323440, Verbindung

HRID 1401851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1401851
Br[C:2]1[S:3][CH:4]=[C:5]([Br:7])[N:6]=1.Cl.[NH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]1.C(N(CC)CC)C.O>CN(C=O)C>[Br:7][C:5]1[N:6]=[C:2]([N:9]2[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][CH2:10]2)[S:3][CH:4]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 27632972,4-Dibromo-1,3-thiazoleHCID 30848514-Piperidone hydrochloride

Produkt 1

HCID 67323440HCID 67323440, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

1 g (4.12 mmol) of 2,4-dibromothiazole was dissolved in 10 ml of DMF, 1.06 g (7.82 mmol) of piperidin-4-one hydrochloride and 2.3 ml (16.47 mmol) of triethylamine were added, and the mixture was stirred at 80° C. for 3 days. The reaction mixture was stirred into 300 ml of water and extracted by shaking with EA. The organic phase was dried over sodium sulfate, filtered and evaporated. The purification was carried out by means of flash chromatography on silica gel.

Aufarbeitung

  1. extractionextracted
  2. stirringby shaking with EA
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customThe purification

Quellen und Nachweise

ORD-Eintrag
ord-9a24ae5764b64fbcb5974be2df6fb266
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08907098B2

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