Ammonia → 7-Bromoquinolin-5-ol

HRID 1402691Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1402691
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[C:4]([O:12]C)[CH:3]=1.Br.N>O>[OH:12][C:4]1[CH:3]=[C:2]([Br:1])[CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 260Hydrogen BromideHCID 712378127-Bromo-5-methoxyquinoline

Produkt 1

HCID 1362166197-Bromoquinolin-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1.5 g (0.0064 mol) of 7-bromo-5-methoxy-quinoline were refluxed with 48% HBr (30 ml) for 20 h. After cooling to room temperature reaction mixture was poured into 100 ml of water and basified with saturated ammonia solution. Product was filtered off, washed with water and dried at 50° C. in vacuo. Yield of 7-bromo-5-hydroxy-quinoline was 600 mg (41%).

Aufarbeitung

  1. customreaction mixture
  2. filtrationProduct was filtered off
  3. washwashed with water
  4. customdried at 50° C. in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-28981c1d283947eaa84e8e876f62703f
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08912173B2

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