[NH:1]1[CH2:4][CH:3]([C:5]([N:7]2[CH2:12][CH2:11][N:10]([CH:13]3[CH2:16][CH2:15][CH2:14]3)[CH2:9][CH2:8]2)=[O:6])[CH2:2]1.[CH3:17][C:18]1[N:23]=[CH:22][C:21]([C:24](Cl)=[O:25])=[CH:20][CH:19]=1.CCN(C(C)C)C(C)C>ClCCl>[CH:13]1([N:10]2[CH2:11][CH2:12][N:7]([C:5]([CH:3]3[CH2:2][N:1]([C:24]([C:21]4[CH:22]=[N:23][C:18]([CH3:17])=[CH:19][CH:20]=4)=[O:25])[CH2:4]3)=[O:6])[CH2:8][CH2:9]2)[CH2:14][CH2:15][CH2:16]1To a stirred solution of 1-(azetidin-3-ylcarbonyl)-4-cyclobutylpiperazine (60 mg, 0.27 mmol) in dichloromethane (1 mL) at 0° C., was added 6-methylpyridine-3-carbonyl chloride (31 mg, 0.32 mmol) and DIPEA (142 μL, 0.81 mmol). After 4 hours the reaction was quenched by addition of saturated aq. NaHCO3 (1 mL) and the aqueous extracted with dichloromethane (2×5 mL), dried (MgSO4), filtered, and concentrated at reduced pressure. Purification by silica FCC (eluting with 90:9:1 Et2O/MeOH/NH3) followed by capture and release on an SCX-2 cartridge (washing with MeOH and releasing with 7M NH3 in MeOH) gave the title compound (17.8 mg, 19%)
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