Methanol → 4-Methoxy-7h-pyrrolo[2,3-d]pyrimidine
Reaktionsgleichung
Cl[C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[OH-:11].[K+].O.[CH3:14]O>>[CH3:14][O:11][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1Komponenten
5
Reaktionsbedingungen
- Temperatur
- 60 °C
Versuchsvorschrift
To 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1, 3.5 g, 23.0 mmol) in 70 mL of methanol, potassium hydroxide (2.3 g, 41.0 mmol) was added and the reaction stirred at 60° C. overnight, then poured into water and extracted with ethyl acetate. The organic layer was separated and dried over sodium sulfate, filtered and the filtrate concentrated under vacuum to provide the desired compound (3, 3.20 g).
Aufarbeitung
- extractionextracted with ethyl acetate
- customThe organic layer was separated
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationthe filtrate concentrated under vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-97cb98cf56f24e0ca4fb2b3d4ee6805f
- Quelldatensatz
- uspto-grants-2014_12
- Patentnummer
- US08912204B2
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