2,4-Dichloro-1,3,5-triazine → 4-Chloro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amine

HRID 1405200Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1405200
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.CCN(C(C)C)C(C)C.[Cl-].[CH3:19][CH:20]([S:22]([CH2:25][C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH3+:29])(=[O:24])=[O:23])[CH3:21]>C1COCC1.CC(O)C>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([NH:29][C:28]2[CH:30]=[CH:31][CH:32]=[C:26]([CH2:25][S:22]([CH:20]([CH3:21])[CH3:19])(=[O:24])=[O:23])[CH:27]=2)[N:7]=1

Komponenten

5

Edukt 3

HCID 178102,4-Dichloro-1,3,5-triazineHCID 81531DiisopropylethylamineHCID 867296113-[(Propan-2-ylsulfonyl)methyl]anilinium chloride

Produkt 1

HCID 891559554-Chloro-N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}-1,3,5-triazin-2-amineAusbeute 268 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22597222Tetrahydrofuran 2-propanolLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 2,4-dichloro-1,3,5-triazine (150 mg, ABCR GmbH & CO. KG) in THF/i-PrOH (1:1; 1.9 mL) DIPEA (0.52 mL) was added at −40° C. Then a suspension of 3-[(propan-2-ylsulfonyl)methyl]anilinium chloride (250 mg) in THF/i-PrOH (1:1, 0.94 mL) was added at this temperature. Under stirring the temperature of the reaction mixture was slowly raised over 3 hours to 0° C. The reaction mixture was then concentrated in vacuo to give the crude title compound (876 mg) which was used without further purification.

Aufarbeitung

  1. additionwas added at this temperature
  2. temperaturewas slowly raised over 3 hours to 0° C
  3. concentrationThe reaction mixture was then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7869f1e9e48f40f3a59f40b90b39107a
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916557B2

Notizen zur Reaktion

Wird geladen…