Hydrazine hydrate (1:1) → HCID 59436165, Verbindung

HRID 1407077Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1407077
[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([O:20]C)=O.O.[NH2:23][NH2:24]>C(O)C>[O:1]=[C:2]1[CH:7]=[CH:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:4]=[C:3]1[C:18]([NH:23][NH2:24])=[O:20]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 1481306HCID 1481306, Verbindung

Produkt 1

HCID 59436165HCID 59436165, VerbindungAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of methyl 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carboxylate (1.019 g, 3.42 mmol) and hydrazine monohydrate (0.3 mL, 6.19 mmol) in ethanol (10 mL) was heated under microwave conditions for 10 min at 120° C. After that time, the reaction was cooled to room temperature and the product was collected by filtration and washed with cold ethanol to give 4-oxo-1-[3-(trifluoromethyl)phenyl]-1,4-dihydropyridazine-3-carbohydrazide (0.607 g, 60%) as bright orange crystals.

Aufarbeitung

  1. filtrationthe product was collected by filtration
  2. washwashed with cold ethanol

Quellen und Nachweise

ORD-Eintrag
ord-77267bdb78ef40b79af875c01ebb37ed
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08916566B2

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