Methyl Methacrylate → Verapamil

HRID 1408273

Reaktionsgleichung

Reaktionsgleichung von HRID 1408273
[CH3:1][CH:2]([C:4]([C:24]1[CH:25]=[CH:26][C:27]([O:32][CH3:33])=[C:28]([O:30][CH3:31])[CH:29]=1)([C:22]#[N:23])[CH2:5][CH2:6][CH2:7][N:8]([CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1)[CH3:9])[CH3:3].Cl.CC(C(OC)=O)=C>>[CH3:3][CH:2]([C:4]([C:24]1[CH:25]=[CH:26][C:27]([O:32][CH3:33])=[C:28]([O:30][CH3:31])[CH:29]=1)([C:22]#[N:23])[CH2:5][CH2:6][CH2:7][N:8]([CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1)[CH3:9])[CH3:1]

Komponenten

3

Edukt 2

HCID 6658Methyl MethacrylateHCID 62969Verapamil Hydrochloride

Produkt 1

HCID 2520Verapamil

Versuchsvorschrift

Weighed quantities of verapamil hydrochloride and Eudragit L100 were mixed in a blender. The mass was granulated using molten compritol. Granules of verapamil thus obtained were further blended using Kollidon SR and lactose, lubricated using magnesium stearate and compressed into tablets.

Aufarbeitung

  1. additionwere mixed in a blender

Quellen und Nachweise

ORD-Eintrag
ord-d47fd98b27b4490fbc9b58a92169d264
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08920837B2

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