1,2-Dichloroethane → HCID 178513561, Verbindung

HRID 1409117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1409117
Br[C:2]1[C:7](Cl)=[CH:6][N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.C(Cl)CCl.[CH:16]1[CH:17]=C[C:19]2[N:24](O)N=[N:22][C:20]=2[CH:21]=1.CN(C=[O:30])C>>[N:9]1[CH:10]=[CH:11][C:3]2[C:4]=1[NH:5][CH:6]=[CH:7][C:2]=2[C:16]1[CH:21]=[C:20]([C:19]([NH2:24])=[O:30])[NH:22][CH:17]=1

Komponenten

5

Edukt 4

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 468355224-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine

Produkt 1

HCID 178513561HCID 178513561, Verbindung

Versuchsvorschrift

To a vial with Compound D′ (0.1 mmol) in DMF (1 mL), EDC (2 equivalent, 0.2 mmol) and HOBt (0.5 equivalent, 0.05 mmol) were added and the reaction mixture was stirred at room temperature for half an hour, amine (1.2 equivalent, 0.12 mmol) was added and the reaction mixture was stirred at room temperature for 2-3 hour. Reverse phase HPLC was used to purify the final compound.

Aufarbeitung

  1. stirringthe reaction mixture was stirred at room temperature for 2-3 hour
  2. customto purify the final compound

Quellen und Nachweise

ORD-Eintrag
ord-f2310ed1b88740c2b2f637a35f217648
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921376B2

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