2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 1410429Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1410429
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

Komponenten

5

Edukt 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

Produkt 1

HCID 23698872Sodium 2,6-difluorobenzoateAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

Aufarbeitung

  1. customsolvents were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-635760b542f24913a0acd03fb0071f95
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921544B2

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