trans-3,5-Difluorocinnamic acid → HCID 178501619, Verbindung

HRID 1410537

Reaktionsgleichung

Reaktionsgleichung von HRID 1410537
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]2[CH2:15][CH2:14][CH:13]([NH:16][CH:17]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[C:18]([O:20][CH3:21])=[O:19])[CH2:12][CH2:11]2)=[CH:2]1.[F:28][C:29]1[CH:30]=[C:31]([CH:37]=[C:38]([F:40])[CH:39]=1)/[CH:32]=[CH:33]/[C:34](O)=[O:35]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C@H:10]2[CH2:15][CH2:14][C@H:13]([NH:16][CH:17]([CH:22]3[CH2:23][CH2:24][N:25]([C:34](=[O:35])/[CH:33]=[CH:32]/[C:31]4[CH:30]=[C:29]([F:28])[CH:39]=[C:38]([F:40])[CH:37]=4)[CH2:26][CH2:27]3)[C:18]([O:20][CH3:21])=[O:19])[CH2:12][CH2:11]2)=[CH:2]1

Komponenten

3

Edukt 2

HCID 5374941trans-3,5-Difluorocinnamic acidHCID 67774409HCID 67774409, Verbindung

Produkt 1

HCID 178501619HCID 178501619, Verbindung

Versuchsvorschrift

The title compound was prepared from methyl 2-(4-(1H-indol-3-yl)cyclohexyl)amino)-2-(piperidin-4-yl)acetate (from Example 24, step A) and trans-3,5-difluorocinnamic acid, by the method of Example 1, step K, giving a solid that was mostly the more polar cyclohexyl diastereomer by LCMS. Mass spectrum (LCMS, APCI pos.) calcd. for C31H35F2N3O3: 536 (M+H). Found: 536.3.

Aufarbeitung

  1. customby the method of Example 1, step K, giving a solid

Quellen und Nachweise

ORD-Eintrag
ord-2ef06bb5c15e40cf9cccf8e4c244993d
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921559B2

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