Potassium Carbonate → HCID 90449363, Verbindung

1-(1′-Acetyl-5-mercaptospiro[indoline-3,3′-pyrrolidin]-1-yl)-2,2,2-trifluoroethanone (26 mg, 0.076 mmol) was dissolved in dimethylformamide (1 mL). Thereafter, potassium carbonate (32 mg, 0.23 mmol) and cyclopentane bromide (23 mg, 0.15 mmol) were added to the above obtained solution, and the thus obtained mixture was then stirred at room temperature for 1.5 hours. Thereafter, the reaction solution was diluted with water, and was then extracted with ethyl acetate. The organic layer was washed with brine, and was then dried over anhydrous magnesium sulfate, followed by concentration in vacuo. The obtained residue was purified by preparative thin-layer chromatography (chloroform:methanol=20:1) to obtain 1-(1′-acetyl-5-(cyclopentylthio)spiro[indoline-3,3′-pyrrolidin]-1-yl)-2,2,2-trifluoroethanone (13 mg, 42%) in the form of a colorless oily product.

1. extractionwas then extracted with ethyl acetate
2. washThe organic layer was washed with brine
3. dry with materialwas then dried over anhydrous magnesium sulfate
4. concentrationfollowed by concentration in vacuo
5. customThe obtained residue was purified by preparative thin-layer chromatography (chloroform:methanol=20:1)

ORD-Eintrag

ord-b2977832c0c44f108d3745049a9b4d7b

Quelldatensatz

uspto-grants-2014_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08921576B2