HCID 58032133, Verbindung → 4-(4-(3,4-Difluorophenyl)piperidin-1-yl)-3,5-difluoroaniline

HRID 1411418Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1411418
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]=[C:15]([C:18]2[CH:23]=[CH:22][C:21]([F:24])=[C:20]([F:25])[CH:19]=2)[CH2:14][CH2:13]1>C1COCC1.[Pd]>[F:25][C:20]1[CH:19]=[C:18]([CH:15]2[CH2:14][CH2:13][N:12]([C:3]3[C:4]([F:11])=[CH:5][C:6]([NH2:8])=[CH:7][C:2]=3[F:1])[CH2:17][CH2:16]2)[CH:23]=[CH:22][C:21]=1[F:24]

Komponenten

4

Edukt 1

HCID 58032133HCID 58032133, Verbindung

Produkt 1

HCID 580320614-(4-(3,4-Difluorophenyl)piperidin-1-yl)-3,5-difluoroanilineAusbeute 100,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 1-(2,6-difluoro-4-nitrophenyl)-4-(3,4-difluorophenyl)-1,2,3,6-tetrahydropyridine (0.67 g, 1.90 mmol) in THF (20 mL) was added 10% Pd on carbon (50 mg). The reaction flask was flushed with N2 gas, and the resulting mixture was vigorously stirred under 1 atm H2 gas for 24 hours. The mixture was filtered through diatomaceous earth and concentrated in vacuo to give the title compound as a solid (0.62 g, 100%).

Aufarbeitung

  1. customThe reaction flask was flushed with N2 gas
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e62e3e82919c4a9e953242d9eec2dc25
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921514B2

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