Water → 1,2-Dimethyl-4-nitro-1H-imidazole

HRID 1412124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1412124
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=1.[C:10]([O-])([O-])=O.[K+].[K+].CI.O>CN(C=O)C>[CH3:10][N:3]1[CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[N:6]=[C:2]1[CH3:1]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178433402HCID 178433402, Verbindung

Produkt 1

HCID 257911,2-Dimethyl-4-nitro-1H-imidazoleAusbeute 45 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 2-methyl-4-nitro-1H-imidazole (10.0 g, 78.7 mmol) and K2CO3 (21.7 g, 160 mmol) in DMF (80 mL) was added CH3I (13.4 g, 94 mmol) dropwise while stirring at room temperature. The mixture was stirred for 2 h. Water (200 mL) was then added to the mixture. The resulting suspension was filtered, washed with water, and dried in vacuo to afford 337a as a white solid (5.0 g, 45%). MS-ESI: [M+H]+ 142.1.

Aufarbeitung

  1. stirringThe mixture was stirred for 2 h
  2. filtrationThe resulting suspension was filtered
  3. washwashed with water
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c7ca81193cfd46fe8e747149ea72db8a
Quelldatensatz
uspto-grants-2014_12
Patentnummer
US08921353B2

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