Carbon Dioxide → 5-Chloro-2-(methylthio)pyrimidine

HRID 1413043Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1413043
[Cl:1][C:2]1[C:3](C(O)=O)=[N:4][C:5]([S:8][CH3:9])=[N:6][CH:7]=1.C(=O)=O>>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([S:8][CH3:9])=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 280Carbon DioxideHCID 7257115-Chloro-2-(methylsulfanyl)pyrimidine-4-carboxylic acid

Produkt 1

HCID 47370635-Chloro-2-(methylthio)pyrimidineAusbeute 89,2 %

Versuchsvorschrift

5-Chloro-2-methylthio-4-pyrimidine carboxylic acid (30 g) was heated at 180°-200° C. until all the solid had melted and the evolution of carbon dioxide had ceased (5 min). The residue was allowed to cool and then washed with several portions of chloroform. The chloroform washings were filtered to remove dark insoluble material and the filtrate was concentrated to give 5-chloro-2-methylthiopyrimidine as a pale brown crystalline solid (21 g, 89%), m.p. 55° C.

Aufarbeitung

  1. custom(5 min)
  2. temperatureto cool
  3. washwashed with several portions of chloroform
  4. filtrationThe chloroform washings were filtered
  5. customto remove dark insoluble material
  6. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-97f3674f964e4f6c8af28d78938cc3ec
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04248618

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