Isopropylamine → 1-Isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

HRID 1414598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1414598
[CH:1]([NH2:4])([CH3:3])[CH3:2].[O:5]1[CH:7]([CH2:8][O:9][C:10]2[S:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[O:16])=[CH:13][N:14]=2)[CH2:6]1>C(O)C>[CH:1]([NH:4][CH2:6][CH:7]([OH:5])[CH2:8][O:9][C:10]1[S:11][C:12]([C:15]([NH:17][CH2:18][CH2:19][CH2:20][CH:21]([CH3:24])[CH2:22][CH3:23])=[O:16])=[CH:13][N:14]=1)([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 20328376N-(4-Methylhexyl)-2-[(oxiran-2-yl)methoxy]-1,3-thiazole-5-carboxamide

Produkt 1

HCID 203285121-Isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

This example illustrates further methods according to the invention of preparing the compounds of formula I to the invention. In this example 0.6 g. of isopropylamine is added to a solution containing 0.3 g. of 1,2-epoxy-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-propane in 20 ml. of anhydrous absolute ethanol, and then allowed to stand for 12 hours at room temperature. The mixture is then evaporated to dryness and the resulting residue chromatographed on silica gel yielding 1-isopropylamino-3-(5-4'-methylhexylaminocarbonylthiazol-2-oxy)-2-propanol.

Aufarbeitung

  1. customaccording to the invention of preparing the compounds of formula I to the invention
  2. additioncontaining 0.3 g
  3. customThe mixture is then evaporated to dryness
  4. customthe resulting residue chromatographed on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-a25f0d63d25743ff821c5d9e551a7e25
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04001421

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