Potassium Hydroxide → 3-Hydroxy-3-phenylpropanoic acid

HRID 1414753

Reaktionsgleichung

Reaktionsgleichung von HRID 1414753
[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6]CC)=[O:5].[OH-].[K+]>C(O)C>[OH:1][CH:2]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH2:3][C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 99818Ethyl 3-phenylhydracrylate, (+-)-

Produkt 1

HCID 929593-Hydroxy-3-phenylpropanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 3-hydroxy-3-phenylpropanoate (19 g, 0.1 mole) was refluxed in a solution of KOH (10 g, 0.2 mole) in ethanol for two hours. The solvent was removed in vacuo and the residue was dissolved in H2O. The H2O solution was extracted with ethyl ether, then acidified with 37% hydrochloric acid. The oily product was extracted out with chloroform and the chloroform was removed in vacuo to yield 10 g (62.5%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in H2O
  3. extractionThe H2O solution was extracted with ethyl ether
  4. extractionThe oily product was extracted out with chloroform
  5. customthe chloroform was removed in vacuo
  6. customto yield 10 g (62.5%)

Quellen und Nachweise

ORD-Eintrag
ord-cdcbffa4f09742e9845325766a34354c
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04002660

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