Sodium borohydride → HCID 68143930, Verbindung

HRID 1414980Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1414980
[CH2:1]([C@:4]12[CH2:12][CH2:11][C:10]3[C:13]4[CH:14]=[CH:15][C:16]([O:21][CH3:22])=[CH:17][C:18]=4[CH2:19][CH2:20][C:9]=3[C@@H:8]1[CH2:7][CH2:6][C:5]2=[O:23])[CH2:2][CH3:3].[BH4-].[Na+]>CO>[CH2:1]([C@:4]12[CH2:12][CH2:11][C:10]3[C:13]4[CH:14]=[CH:15][C:16]([O:21][CH3:22])=[CH:17][C:18]=4[CH2:19][CH2:20][C:9]=3[C@@H:8]1[CH2:7][CH2:6][C@@H:5]2[OH:23])[CH2:2][CH3:3]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 54182015(±)-3-Methoxy-13-propylgona-1,3,5(10),8-tetraen-17-one

Produkt 1

HCID 68143930HCID 68143930, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Add 13β-propyl-3-methoxygona-1,3,5(10),8-tetraen-17-one (3.5 g.) to a solution of sodium borohydride (1.16 g.) in methanol (120 cc.). Heat the reaction mixture to reflux with stirring for 30 minutes. Concentrate the resulting solution, adjust its pH to 6 with aqueous acetic acid and filter off the resulting white precipitate which is the title product, (3.1 g.), m.p. 134°-8°; ultra-violet absorption peak at 278 mμ (ε15,350); infrared showed a band due to hydroxyl but no ketone present.

Aufarbeitung

  1. temperatureHeat the reaction mixture
  2. temperatureto reflux
  3. concentrationConcentrate the resulting solution
  4. filtrationfilter off the resulting white precipitate which

Quellen und Nachweise

ORD-Eintrag
ord-d6002339812e4a51a1f64a611fd645b3
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04002746

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