Acetic Acid → 4-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate

HRID 1416451Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1416451
[OH:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.[C:24]([OH:27])(=[O:26])[CH3:25]>CC(C)=O>[C:24]([OH:27])(=[O:26])[CH3:25].[OH:1][C@@H:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 154091264-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline

Produkt 1

HCID 675829364-[trans-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetateAusbeute 58,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

4-[(1R,2R)-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 7) (1.1 g) is dissolved in acetone (30 ml), and thereto is added acetic acid (0.23 g). The precipitated crystals are separated by filtration and recrystallized from acetone to give 4-[(1R,2R)-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.77 g).

Aufarbeitung

  1. customThe precipitated crystals are separated by filtration
  2. customrecrystallized from acetone

Quellen und Nachweise

ORD-Eintrag
ord-ce76b2f81a9c4e598bc2c87c0bc5acbe
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05912247

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