HCID 9926017, Verbindung → 1-(2-Methylphenyl)-4-oxo-6-methyl-4,5-dihydropyrrolo[3,2-c]quinoline

HRID 1416679Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1416679
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[NH:13][C:12](=[O:22])[C:11]=2[CH2:10][CH2:9]1>C1(OC2C=CC=CC=2)C=CC=CC=1.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[NH:13][C:12](=[O:22])[C:11]=2[CH:10]=[CH:9]1

Komponenten

4

Edukt 1

HCID 9926017HCID 9926017, Verbindung

Produkt 1

HCID 157498281-(2-Methylphenyl)-4-oxo-6-methyl-4,5-dihydropyrrolo[3,2-c]quinolineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

1-(2-methylphenyl)-4-oxo-6-methyl-2,3,4,5-tetra hydropyrrolo[3,2-c]quinoline (290 mg, 1.0 mmol) was dissolved in 20 ml of diphenyl ether and 40 mg of 5% palladium/carbon was added. The reaction mixture was heated for 4 hours. The reaction mixture was cooled to the room temperature and directly purified by silica gel chromatography to obtain 245 mg of desired compound as solid in 85% of yield.

Aufarbeitung

  1. temperatureThe reaction mixture was heated for 4 hours
  2. customdirectly purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-eb7118dd4a19490585f202b86d2c4d03
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05914402

Notizen zur Reaktion

Wird geladen…