Hydrochloric Acid → HCID 67589095, Verbindung

HRID 1416725

Reaktionsgleichung

Reaktionsgleichung von HRID 1416725
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:29])[CH2:9][NH:10][CH:11]([CH3:28])[CH2:12][C:13]2[CH:27]=[CH:26][C:16]3[O:17][C:18]([C:23]([OH:25])=[O:24])([C:20]([OH:22])=[O:21])[O:19][C:15]=3[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:30]([O:32][CH2:33][CH2:34]O)[CH3:31].Cl>>[ClH:1].[CH2:16]([O:17][CH2:18][CH2:20][O:24][C:23]([C:18]1([C:20]([O:22][CH2:34][CH2:33][O:32][CH2:30][CH3:31])=[O:21])[O:17][C:16]2[CH:26]=[CH:27][C:13]([CH2:12][CH:11]([NH:10][CH2:9][CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[OH:29])[CH3:28])=[CH:14][C:15]=2[O:19]1)=[O:25])[CH3:15]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 8076Glycol monoethyl etherHCID 42813555-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

Produkt 1

HCID 67589095HCID 67589095, Verbindung

Versuchsvorschrift

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-ethoxyethanol according to the procedure of Example 1 as an oily off-white gummy solid; 1H NMR (300 MHz, CDCl3): δ 1.10-1.20 (t overlaps with d, J=6.9 Hz, 9H), 1.31-1.41 (brm, 2H), 2.75-2.90 (brm, 1H), 3.10-3.30 (brm, 2H), 3.50 (brq, J=6.9 Hz, 4H), 3.62-3.71 (brm, 4H), 4.37-4.47 (brm, 4H), 5.30-5.70 (brm, 2H), 6.70-6.90 (brm, 4H), 7.19-7.50 (brm, 3H), 8.50-8.85 (brs, 1H), 9.90-10.30 (brs, 1H); MS (ES) m/z (relative intensity): 566 (M+ -HCl, (60).

Quellen und Nachweise

ORD-Eintrag
ord-dfceb58475aa42f8bf76e230c0485996
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05914339

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