Hydrochloric Acid → N-Lauroylglycine

HRID 1417865

Reaktionsgleichung

Reaktionsgleichung von HRID 1417865
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[OH-].[Na+].[C:8](Cl)(=[O:20])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].Cl>CCOCC>[C:8]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[O:20])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 750GlycineHCID 8166Dodecanoyl chlorideHCID 14798Sodium Hydroxide2×

Produkt 1

HCID 346152N-LauroylglycineAusbeute 84,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of glycine in a 1 N-sodium hydroxide, an ether solution of n-dodecanoyl chloride and a 1 N-aqueous solution of sodium hydroxide were dropped simultaneously and the mixture was stirred for 1 hour. The reaction mixture was then neutralized with hydrochloric acid and ether was removed from the solution. N-n-dodecanoylglycine was obtained from the remaining reactant after the purification by column chromatography with the yield of 84.7%. The melting point of the product was 115.5° to 116.7° C.

Aufarbeitung

  1. customwas removed from the solution

Quellen und Nachweise

ORD-Eintrag
ord-d6b841397c0148dcaa9c544bff0e866c
Quelldatensatz
uspto-grants-1999_03
Patentnummer
USRE036138

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