Hydrochloric Acid → N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide hydrochloride

HRID 1418189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1418189
[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:5])([CH3:4])[CH3:3]>O1CCOCC1.C(OCC)C>[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:3])([CH3:4])[CH3:5]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 19348478HCID 19348478, Verbindung

Produkt 1

HCID 19348562N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A 4N solution of hydrogen chloride in dioxane was added to a solution of N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide (prepared as described in Preparation 26A) in diethyl ether, and the precipitate which separated out was collected by filtration and washed with hexane to give the desired hydrochloride, melting at 102°-106° C.

Aufarbeitung

  1. customthe precipitate which separated out
  2. filtrationwas collected by filtration
  3. washwashed with hexane

Quellen und Nachweise

ORD-Eintrag
ord-bf3bf3f32ca040d7a2142ed252ab3f47
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05880147

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