Water → Methyl 2-Ethylthio-4-methyl-1-[2'-(5-trichloromethyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methylthieno[3,4-d]imidazole-6-carboxylate

To an ice-cooling solution of methyl 2-ethylthio-4-methylthieno[3,4-d]imidazole-6-carboxylate (3 g) in DMF (20 ml) was added sodium hydride (60%, oil) (0.56 g), and the mixture was stirred for 10 minutes. To the ice-cooling mixture was added [2'-(5-trichloromethyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl bromide (6.1 g), and the mixture was stirred for two hours at room temperature. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous saline solution. The solvent was distilled off under reduced pressure, and the residue was purified by column chromatography on silica gel to afford the title compound as a pale yellow syrupy product (4.15 g, 58%).

1. stirringthe mixture was stirred for two hours at room temperature
2. extractionthe mixture was extracted with ethyl acetate
3. washThe organic layer was washed with a saturated aqueous saline solution
4. distillationThe solvent was distilled off under reduced pressure
5. customthe residue was purified by column chromatography on silica gel

ORD-Eintrag

ord-58fca5ce3f3a4b10bba6b0ee080be4d2

Quelldatensatz

uspto-grants-1999_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05883111