Methanol → Methyl 2-chloro-6-fluorobenzoate

Temperatur

60 °C

A 50-mL round-bottom flask was equipped with a magnetic stir bar, reflux condenser, thermometer, nitrogen inlet, and a heating mantle attached to a temperature controller. The flask was charged with 2-chloro-6-fluorobenzoic acid (8.30 g, 47.55 mmol), methanol (15 g), and concentrated sulfuric acid (1 g). The reaction mixture was heated to 60° C. for seven days, then cooled to room temperature. Ethyl ether (50 mL) was added; the reaction mixture was transferred to a separatory funnel and washed with 1M sodium hydroxide solution (3×40 mL), then with water (40 mL). The organic layer was dried over sodium sulfate. The solvent was removed by evaporation under reduced pressure and the residue was dried under vacuum to give 5.34 g of methyl 2-chloro-6-fluorobenzoate as a yellow oil.

1. customA 50-mL round-bottom flask was equipped with a magnetic stir bar
2. temperaturereflux condenser
3. customthermometer, nitrogen inlet, and a heating mantle attached to a temperature controller
4. temperaturecooled to room temperature
5. customthe reaction mixture was transferred to a separatory funnel
6. washwashed with 1M sodium hydroxide solution (3×40 mL)
7. dry with materialThe organic layer was dried over sodium sulfate
8. customThe solvent was removed by evaporation under reduced pressure
9. customthe residue was dried under vacuum

ORD-Eintrag

ord-df0b072c2bf54a44ba8bc87e50e813e6

Quelldatensatz

uspto-grants-1999_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05886210