HCID 9906877, Verbindung → HCID 9818192, Verbindung

HRID 1420773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1420773
Br[C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1.[CH3:22][O-:23].[Na+]>>[CH3:22][O:23][C:2]1[CH:9]=[C:8]2[N:4]([C:5]3[C:13]([C:14]4[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=4)=[CH:12][S:11][C:6]=3[C:7]2=[O:10])[CH:3]=1

Komponenten

3

Edukt 2

HCID 9906877HCID 9906877, VerbindungHCID 10942334Sodium Methoxide

Produkt 1

HCID 9818192HCID 9818192, Verbindung

Versuchsvorschrift

1 equivalent of the compound obtained in Example 12 is stirred, at ambient temperature, into a solution of sodium methanolate. After 12 hours' reaction, the reaction mixture is concentrated under reduced pressure. The residue is taken up in dichloromethane; the organic phase is then washed with a saturated NaCl solution, dried over sodium sulphate and then concentrated under reduced pressure. Chromatography on silica gel (dichloromethane) allows the expected product to be isolated.

Aufarbeitung

  1. customAfter 12 hours' reaction
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. washthe organic phase is then washed with a saturated NaCl solution
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated under reduced pressure
  6. customto be isolated

Quellen und Nachweise

ORD-Eintrag
ord-7cd672cc323f4c6685717e511b5d3afb
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06071945

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