Cyclohexene → HCID 385194, Verbindung

HRID 1421877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1421877
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[C:4](Cl)[N:3]=1.C1CCCCC=1>[OH-].[Pd+2].[OH-].C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][N:3]=1

Komponenten

5

Edukt 2

HCID 8079CyclohexeneHCID 385223HCID 385223, Verbindung

Produkt 1

HCID 385194HCID 385194, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To 2-amino-6-chloro-4-[[(1-hydroxymethyl-1-cyclobutyl)methyl]amino]pyrimidine (1.46 g, 6.0 mmol) were added ethanol (40 ml), cyclohexene (15 ml) and palladium hydroxide (0.2 g) in a nitrogen stream, and the mixture was refluxed for 2 hours. The reaction mixture was filtered and the solvent in the filtrate was distilled away under reduced pressure to give white amorphous crystals (1.34 g, quantitative).

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 hours
  2. filtrationThe reaction mixture was filtered
  3. distillationthe solvent in the filtrate was distilled away under reduced pressure
  4. customto give white amorphous crystals (1.34 g, quantitative)

Quellen und Nachweise

ORD-Eintrag
ord-239085a746b040f697a4476dde4d800f
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06080750

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