Acetic Anhydride → N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-acetamide

HRID 1422231Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1422231
Cl.[NH2:2][CH2:3][C:4]1[CH:13]=[C:12]([Br:14])[CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2.[C:17](OC(=O)C)(=[O:19])[CH3:18].C(N(CC)CC)C>CN(C)C=O>[Br:14][C:12]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2)=[C:4]([CH2:3][NH:2][C:17](=[O:19])[CH3:18])[CH:13]=1

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 18706500HCID 18706500, Verbindung

Produkt 1

HCID 18706505N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

50 mg (0.19 mmol) of 5-aminomethyl-7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline hydrochloride are suspended in 4 ml of N,N-dimethylformamide and stirred at 20° C. for 24 hours with 0.02 ml (1.2 equiv.) of acetic anhydride and 0.059 ml (2.2 equiv.) of triethylamine. The solvent is concentrated by evaporation, and the solid is suspended in diethyl ether, filtered off and washed with methanol and diethyl ether. After drying under a high vacuum, the title compound is obtained in the form of a white solid.

Aufarbeitung

  1. concentrationThe solvent is concentrated by evaporation
  2. filtrationfiltered off
  3. washwashed with methanol and diethyl ether
  4. customAfter drying under a high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-22f4f01f53a6475285274e50acbb0726
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06080743

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